High school teacher Hugh Nelson, Amgen scientist Rick Jacobsen, and biology professor Marty Ikkanda discussed the early origins of the Amgen Biotech Experience (ABE), including their experiences with the program founder Bruce Wallace, and its tremendous growth over the past 30 years. Now in 10 sites across the United States and 12 additional countries globally, ABE has impacted nearly 850,000 students. The program continues to evolve and adapt to meet the growing and changing demand for high-quality scientific lab experiences for high school students around the world.